A paradigm shift in public health and medicine has broadened the field from a singular focus on the ill effects of negative states and psychopathology to an expanded view that examines protective psychological assets that may promote improved physical health and longevity. We summarize recent evidence of the link between psychological well-being and physical health, with particular attention to outcomes of mortality and chronic disease incidence and progression. Within this evolving discipline there remain controversies and lessons to be learned. We (...) discuss measurement-related challenges, concerns about the quality of the evidence, and other shortcomings in the field, along with a brief discussion of hypothesized biobehavioral mechanisms involved. Finally, we suggest next steps to move the field forward. (shrink)

Processed pseudogenes may serve as a genetic reservoir for evolutionary innovation. Here, we argue that through the activity of long interspersed element‐1 retrotransposons, processed pseudogenes disperse coding and noncoding sequences rich with regulatory potential throughout the human genome. While these sequences may appear to be non‐functional, a lack of contemporary function does not prohibit future development of biological activity. Here, we discuss the dynamic evolution of certain processed pseudogenes into coding and noncoding genes and regulatory elements, and their implication in (...) wide‐ranging biological and pathological processes. Also see the video abstract here: https://youtu.be/iUY_mteVoPI. (shrink)

ObjectiveTo examine measurement agreement between a vocabulary test that is administered in the standardized manner and a version that is administered with a brain-computer interface.MethodThe sample was comprised of 21 participants, ages 9–27, mean age 16.7 years, 61.9% male, including 10 with congenital spastic cerebral palsy, and 11 comparison peers. Participants completed both standard and BCI-facilitated alternate versions of the Peabody Picture Vocabulary Test - 4. The BCI-facilitated PPVT-4 uses items identical to the unmodified PPVT-4, but each quadrant forced-choice item (...) is presented on a computer screen for use with the BCI.ResultsMeasurement agreement between instruments was excellent, including an intra-class correlation coefficient of 0.98, and Bland-Altman plots and tests indicating adequate limits of agreement and no systematic test version bias. The mean standard score difference between test versions was 2.0 points.ConclusionThese results demonstrate that BCI-facilitated quadrant forced-choice vocabulary testing has the potential to measure aspects of language without requiring any overt physical or communicative response. Thus, it may be possible to identify the language capabilities and needs of many individuals who have not had access to standardized clinical and research instruments. (shrink)

The National Science Foundation's Second Merit Criterion, or Broader Impacts Criterion , was introduced in 1997 as the result of an earlier Congressional movement to enhance the accountability and responsibility as well as the effectiveness of federally funded projects. We demonstrate that a robust understanding and appreciation of NSF BIC argues for a broader conception of research ethics in the sciences than is currently offered in Responsible Conduct of Research training. This essay advocates augmenting RCR education with training regarding broader (...) impacts. We demonstrate that enhancing research ethics training in this way provides a more comprehensive understanding of the ethics relevant to scientific research and prepares scientists to think not only in terms of responsibly conducted science, but also of the role of science in responding to identified social needs and in adhering to principles of social justice. As universities respond to the mandate from America COMPETES to “provide training and oversight in the responsible and ethical conduct of research”, we urge institutions to embrace a more adequate conception of research ethics, what we call the Ethical Dimensions of Scientific Research, that addresses the full range of ethical issues relevant to scientific inquiry, including ethical issues related to the broader impacts of scientific research and practice. (shrink)

In a fair, infinite lottery, it is possible to conclude that drawing a number divisible by four is strictly less likely than drawing an even number; and, with apparently equal cogency, that drawing a number divisible by four is equally as likely as drawing an even number.

In this essay we develop and argue for the adoption of a more comprehensive model of research ethics than is included within current conceptions of responsible conduct of research (RCR). We argue that our model, which we label the ethical dimensions of scientific research (EDSR), is a more comprehensive approach to encouraging ethically responsible scientific research compared to the currently typically adopted approach in RCR training. This essay focuses on developing a pedagogical approach that enables scientists to better understand and (...) appreciate one important component of this model, what we call intrinsic ethics . Intrinsic ethical issues arise when values and ethical assumptions are embedded within scientific findings and analytical methods. Through a close examination of a case study and its application in teaching, namely, evaluation of climate change integrated assessment models, this paper develops a method and case for including intrinsic ethics within research ethics training to provide scientists with a comprehensive understanding and appreciation of the critical role of values and ethical choices in the production of research outcomes. (shrink)

This collection of essays, offered in honor of the distinguished career of prominent political philosophy professor Clifford Orwin, brings together internationally renowned scholars to provide a wide context and discuss various aspects of the virtue of “humanity” through the history of political philosophy.

Galileo's refutation of the speed-distance law of fall in his Two New Sciences is routinely dismissed as a moment of confused argumentation. We urge that Galileo's argument correctly identified why the speed-distance law is untenable, failing only in its very last step. Using an ingenious combination of scaling and self-similarity arguments, Galileo found correctly that bodies, falling from rest according to this law, fall all distances in equal times. What he failed to recognize in the last step is that this (...) time is infinite, the result of an exponential dependence of distance on time. Instead, Galileo conflated it with the other motion that satisfies this ‘equal time’ property, instantaneous motion. (shrink)

In this reply, we respond to the comments of Palmerino and Laird on our article, "Galileo's Refutation of the Speed Distance Law of Fall Rehabilitated," published in the same issue of Centaurus.

In this essay we develop and argue for the adoption of a more comprehensive model of research ethics than is included within current conceptions of responsible conduct of research (RCR). We argue that our model, which we label the ethical dimensions of scientific research (EDSR), is a more comprehensive approach to encouraging ethically responsible scientific research compared to the currently typically adopted approach in RCR training. This essay focuses on developing a pedagogical approach that enables scientists to better understand and (...) appreciate one important component of this model, what we call intrinsic ethics . Intrinsic ethical issues arise when values and ethical assumptions are embedded within scientific findings and analytical methods. Through a close examination of a case study and its application in teaching, namely, evaluation of climate change integrated assessment models, this paper develops a method and case for including intrinsic ethics within research ethics training to provide scientists with a comprehensive understanding and appreciation of the critical role of values and ethical choices in the production of research outcomes. (shrink)

More than two decades of work in vision posits the existence of dual-learning systems of category learning. The reflective system uses working memory to develop and test rules for classifying in an explicit fashion, while the reflexive system operates by implicitly associating perception with actions that lead to reinforcement. Dual-learning systems models hypothesize that in learning natural categories, learners initially use the reflective system and, with practice, transfer control to the reflexive system. The role of reflective and reflexive systems in (...) auditory category learning and more specifically in speech category learning has not been systematically examined. In this article, we describe a neurobiologically constrained dual-learning systems theoretical framework that is currently being developed in speech category learning and review recent applications of this framework. Using behavioral and computational modeling approaches, we provide evidence that speech category learning is predominantly mediated by the reflexive learning system. In one application, we explore the effects of normal aging on non-speech and speech category learning. Prominently, we find a large age-related deficit in speech learning. The computational modeling suggests that older adults are less likely to transition from simple, reflective, unidimensional rules to more complex, reflexive, multi-dimensional rules. In a second application, we summarize a recent study examining auditory category learning in individuals with elevated depressive symptoms. We find a deficit in reflective-optimal and an enhancement in reflexive-optimal auditory category learning. Interestingly, individuals with elevated depressive symptoms also show an advantage in learning speech categories. We end with a brief summary and description of a number of future directions. (shrink)

A descriptive norm is a behavioral rule that individuals follow when their empirical expectations of others following the same rule are met. We aim to provide an account of the emergence of descriptive norms by first looking at a simple case, that of the standing ovation. We examine the structure of a standing ovation, and show it can be generalized to describe the emergence of a wide range of descriptive norms.

Nathaniel Dorsky _Devotional Cinema_ Berkeley, California: Tuumba Press, 2003 ISBN 1-931157-05-7 52 pp.

Integrated pest management has emerged as an important means of managing agricultural pests. Since the mid-1980s, the emphasis in IPM has shifted toward biologically-intensive and participatory research and extension approaches. Finding better means for solving pest problems is high on the agenda for most farmers, and farmers often have significant pest management knowledge and interest in IPM experimentation. This paper describes an approach to participatory IPM research that is being implemented by the IPM Collaborative Research Support Program (IPM CSRP). The (...) approach emphasizes on-farm research with an extrapolation domain beyond the single farm, and in some cases beyond the local region or country. It considers many factors beyond the farm and research station that influence the generation and adoption of IPM technologies and strategies. It emphasizes linkages among farmers, scientists, consumers, bankers, marketers/processors, and policy makers in IPM research priority setting, conduct, and evaluation. The interdisciplinary approach described in the paper is illustrated with a case study from the Philippines. Lessons and conclusions draw on its recent application in other sites as well. (shrink)

The Planteome project provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus of plant genomics, phenomics and genetics data. The reference ontologies include the Plant Ontology, Plant Trait Ontology, and the Plant Experimental Conditions Ontology developed by the Planteome project, along with the Gene Ontology, Chemical Entities of Biological Interest, Phenotype and Attribute Ontology, and others. The project also provides (...) access to species-specific Crop Ontologies developed by various plant breeding and research communities from around the world. We provide integrated data on plant traits, phenotypes, and gene function and expression from 95 plant taxa, annotated with reference ontology terms. (shrink)

In Democracy and the Claims of Nature, the leading thinkers in the fields of environmental, political, and social theory come together to discuss the tensions and sympathies of democratic ideals and environmental values. The prominent contributors reflect upon where we stand in our understanding of the relationship between democracy and the claims of nature. Democracy and the Claims of Nature bridges the gap between the often competing ideals of the two fields, leading to a greater understanding of each for the (...) other. (shrink)

U.S. immigration policies and enforcement can make immigrants fearful of accessing healthcare. Although current immigration policies restrict enforcement in “sensitive locations” including healthcare facilities, there are reports of enforcement actions in such settings.

In this section-by-section commentary, Benardete argues that Plato's _Republic_ is a holistic analysis of the beautiful, the good, and the just. This book provides a fresh interpretation of the _Republic_ and a new understanding of philosophy as practiced by Plato and Socrates. "Cryptic allusions, startling paradoxes, new questions... all work to give brilliant new insights into the Platonic text."—Arlene W. Saxonhouse, _Political Theory_.

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For economists, sustainability and environmental valuation are connected in two ways. At the micro level, proper environmental valuation is required if projects are to be approved and rejected consistently with sustainability requirements. This is cost benefit analysis. At the macro level, many take the view that sustainability requires that national income measurement be modified so as to account for environmental damage. Such natural resource accounting is possible only if environmental damage is valued for incorporation into the economic accounts. The paper (...) reviews the techniques that economists have developed for environmental valuation. In regard to cost benefit analysis and sustainability, it is noted that the technique on which most interest focuses, the Contingent Valuation Method, involves the extension of the domain of consumer demand analysis to include the natural environment. Contributions questioning the appropriateness of this are reviewed, and it is argued that they merit more attention from economists than they have received to date. In regard to natural resource accounting, it is argued that while there is little prospect of it achieving what its proponents claim for it, the modelling that it necessarily implies has the potential to both clarify valuation issues and play an important role in informing the policy process. (shrink)

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In lieu of an abstract, here is a brief excerpt of the content:Leibniz and Bayle: Manicheism and Dialectic DAVID NORTON LEIBNIZ' CLAIM that this is the "best of all possible worlds" has seemed so prima facie absurd that his critics have often considered the assertion adequately refuted by their pointing to things which are clearly "bad" and which might conceivably be "better." The paradigm case is Voltaire's Candide, which is certainly an effective refutation of Leibniz' claim at this level. (...) We can, however, by taking another point of view find what appear to be other absurdities in Leibniz' metaphysics. The point of view I wish to take, or attempt to take, is that of Pierre Bayle. I wish to suggest some objections to Leibniz which Bayle may have felt, but which he did not make explicit. Such an undertaking will, hopefully, add to our understanding of both Leibniz and Bayle. I What I propose to do is unorthodox, or at least unusual, and for that reason it is extremely important that the reader have from the very outset a clear idea of what is being undertaken. I can best clarify my aims, I think, by first attending briefly to some historical matters. Between 1695 and 1699 Bayle and Leibniz carried on a lively controversy over the latter's metaphysical views, though the debate was limited almost entirely to the notion of pre-established harmony. This controversy is well enough known that we need not stop over its details; in summary, Bayle first admits delight at what appears to be a new metaphysical explanation of the union of mind and body, but then goes on to argue that, after all, Leibniz' system is either no more than a reformulation of occasionalism, or impossible, since it violates clear and accepted metaphysical canons? Now, so far as we know, Bayle did not comment further on Leibniz' metaphysics, though the latter was * I wish to thank Prof. Harry M. Bracken, Arizona State University, and Prof. Richard H. Popkin, University of California, San Diego, for the suggestions and criticisms which they made of an earlier form of this paper. Their suggestions were all enlightening, if not all adopted-meaning, of course, that they would probably not agree with all that I here suggest. x Pierre Bayle, Dictionaire historique et critique, 5=. 6dition, revue, corrig6e, et augment6e, avec la vie de l'auteur, par Mr. Des Maizeaux, 4 tomes (Amsterdam, Leide. La Haye, Utrecht: 1740), article "Rorarius," reins. H. and L. For a fuller account of the Bayle-Leibniz controversy, see Austin Farrer, "Editor's Introduction," in G. W. Leibniz, Theodicy, ed. Austin Farrer, trans. E. M. Huggard (London: 1951), pp. 7-47, esp. pp. 33-47. 24 HISTORY OF PHILOSOPHY eager to continue the controversy, and did so, his final effort being a gigantic one, the Essais de Thdodicde. Unfortunately, Bayle died before the Thdodicde was published and was deprived accordingly of any opportunity to reply to it. Bayle did, however, leave in the Dictionaire historique et critique a number of arguments against various metaphysical positions. The point of my paper is to show that certain of these arguments are applicable to Leibniz' system, and that applied to that system they reveal features of it which we might otherwise have overlooked. Bayle adduces arguments which seem with only slight modification to point directly at Leibniz--though without indicating that he has Leibniz in mind. I hope first of all to show what these arguments are and in what sense they refute Leibniz. I have said that Bayle gives no indication that these arguments of his apply to Leibniz; strictly speaking, this is correct. This does not mean, however, that I am understaking an unjustified wild goose chase through the Dictionaire : Bayle himself offers the motivation which has led to this study when he says in "Rorarius" (rem. L) that he has withheld some objections to Leibniz' opinions on the ground that these are no more objections to Leibniz than to certain other philosophers: "Je m'abstiens aussi de toutes les Objections qui ne sont pas plus contraires ~t son sentiment qu'~t celui de quelques autres Philosophes." In one sense then this paper can be thought of as my speculations of what these waived objections are... (shrink)